Fig. 8
From: Downregulation of FASN in granulosa cells and its impact on ovulatory dysfunction in PCOS
All ovulation events are triggered by an LH surge, engaged in oocyte maturation, cumulus expansion, and follicle rupture. Downregulation of FASN expression in PCOS results in block of ovulation by ERK1/2 phosphorylation, hence suppressing C/EBPβ and other ovulatory genes