Fig. 1

Inactivating germline and somatic SMARCA4 mutations identified in SCCOHT. A representation of the primary structure of the SMARCA4 protein is shown with exon locations noted above. All germline mutations occurred in cohort are marked in blue, somatic mutations are in orange, and unknown types are marked by purple. QLQ, Gln, Leu, Gln motif; HSA, helicase/SANT-associated domain; BRK, Brahma and Kismet domain; DEXDc, DEAD-like helicase superfamily domain; SNF2_N, SNF2 family N-terminal domain; HELICc, helicase superfamily C-terminal domain; Bromo, bromodomain