Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type

Table 1 SMARCA4 mutation in sccohts

	Germline mutation		Somatic mutation 1		Somatic mutation 2		SMARCA4 IHC
Sample ID	Gene	Protein	Gene	Protein	Gene	Protein	SMARCA4 IHC
SCC-01	c.3546 + 2T > C	Not applicable	LOH		Not applicable		Loss
SCC-02	Not present		c.2973 + 1G > A	Not applicable	LOH		Loss
SCC-03	Not present		c.939_940insT	p.A314fs	c.2631 C > A	p.Y877*	Loss
SCC-04	Not present		Not present		Not present		Normal
SCC-05	Not present		c.4170 + 1G > T	Not applicable	LOH		Loss
SCC-06	Not present		Not present		Not present		Normal
SCC-07	c.1742_1745del	p.K581fs	LOH		Not applicable		Loss
SCC-08	Not present		c.3081 + 1G > T	Not applicable	LOH		Loss
SCC-09	c.1119–2 A > G	Not applicable	LOH		Not applicable		Loss
SCC-10	Not available		c.2123 + 1G > T	Not applicable	c.2859 + 5G > A	Not applicable	Loss
SCC-11	Not available		c.2506–2 A > G	Not applicable	LOH		Loss
SCC-12	Not present		c.917_941del	p.Gln306fs	Not present		Loss
SCC-13	Not present		c.1709_1722del	p.Gln570ProfsTer76	LOH		Loss
SCC-14	c.274 C > T	p.Gln92Ter	LOH		Not applicable		Loss
SCC-15	c.3229 C > T	p.Arg1077Ter	LOH		Not applicable		Loss

Not applicable, germline and somatic mutations already identified; not available, DNA not available; not present, no mutation present; IHC, immunohistochemistry

ISSN: 1757-2215