Fig. 3

Screening of tumor-specific age-related genes. A Volcano plot of differential gene expression from GSE66957. B Volcano plot of differential gene expression from GSE54388. C Venn diagram identifying tumor-specific age-related genes. D PPI network analysis of 14 candidate genes. E–F KEGG and GO enrichment analyses of the 14 genes. (G-I) Machine learning-based selection of key genes. J Expression levels of key genes in tumor and normal tissues, stratified by age