Table 1 Clinical research on the treatment of DOR with CHM formulas
From: The role of Chinese herbal medicine in diminished ovarian reserve management
Pattern of syndrome | TCM formulas | Ingredients | Effects | Object (T/ C) | Overall efficacy rate | Period of treatment | Combined | Indicators of improvement | Ref |
|---|---|---|---|---|---|---|---|---|---|
Kidney Deficiency and Boold Stasis syndrome | Zishen Yijing Huoxue Decoction | Glycyrrhizae Radix et Rhizoma, Cyperus rotundus L, Ziziphi Spinosae Semen, Bupleuri Radix, Poria, Chuanxiong Rhizoma, Angelicae Sinensis Radix, Spatholobi Caulis, Corni Fructus, Lycii Fructus, Rehmanniae Radix, Epimedium brevicornu Maxim., Eucommia ulmoides, Codonopsis Radix, Cuscuta chinensis | Tonify the kidneys, invigorate blood circulation. | 60/60 | 88.33%/71.67% | 6 months | Estradiol valerate cyproterone tablets | FSH, RI↓ AFC, E2,AMH, EDV, PSV, CD3+, CD4+, CD4+/CD8+ ↑ | [26] |
Kidney Qi deficiency with Qi stagnation syndrome | Yijing Huchao Decoction | Cuscuta chinensis, Rubi Fructus, Curculigo Gaertn, Rhizoma Epimedii, Cistanches Herba, Cyperus rotundus L, Curcuma longa L, Angelica sinensis, Paeoniae Radix Alba, Ligusticum chuanxiong hort, Eupatorium japonicum Thunb, Fluoritum, Rehmannia glutinosa, Citri Reticulatae Pericarpium, Bupleuri Radix, Glycyrrhiza, Salvia miltiorrhiza Bunge, Poria | Tonify the kidneys, soothe the liver, nourish the blood, and regulate menstruation | 44/4 | 68.18%/45.45% | 3 months | Letrozole | FSH, LH↓AFC, E2, AMH↑ | [24] |
Cold congealing and blood stasis syndrome | Wenjing Decoction | Evodia rutaecarpa, Ophiopogon japonicus, Angelicae Sinensis Radix, Asini Corii Colla, Ligusticum chuanxiong hort, Paeoniae Radix Rubra, Codonopsis pilosula, Pinellia ternata, Glycyrrhiza uralensis, CassiaTwig, Ziziphus jujuba Mill, Zingiber officinale Roscoe, Glucidtemns | Nourish the blood, warm the channels, and dispel cold to remove blood stasis. | 169/169/169 | 71.0%/81.7%/92.3% | 3 months | NA | FSH, LH, FSH/ LH↓, AFC, E2, AMH, OV↑ | [31]. |
Kidney Qi deficiency syndrome | Qizi Yishen Lichong Decoction | Evodia rutaecarpa, Ophiopogon japonicus, Angelicae Sinensis Radix, Asini Corii Colla, Ligusticum chuanxiong hort, Paeoniae Radix Rubra, Codonopsis pilosula, Pinellia ternata, Glycyrrhiza uralensis, CassiaTwig, Ziziphus jujuba Mill, Zingiber officinale Roscoe, Glucidtemns | Benefit the kidneys and replenish essence, regulate the Chong (penetrating) vessel and nourish the blood. | 30/30 | 86.7%/83.3% | 3 months | Femerton | FSH↓, AMH↑ | [30] |
Kidney Yin deficiency syndrome | Kuntai Capsules | Scutellaria baicalensis Georgi, Coptis chinensis, Rehmanniae Radix, Poria, Cynanchum otophyllum Schneid, Asini Corii Colla | Tonify the kidneys and boost qi, nourish yin, and invigorate blood circulation. | 47/47 | NA | 3 months | Femerton | FSH, E2, LH↓, AFC↑ | [32] |
Liver Qi stagnation with Kidney deficiency syndrome | Jiawei Tiaogan Decoction | Cynanchum otophyllum Schneid, Angelicae Sinensis Radix, Cyperus rotundus L, Curcumae Radix, Bupleuri Radix, Aurantii Immaturus Fructus, Citri Reticulatae Pericarpium, Trichosanthis Fructus, Cuscuta chinensis, Ligustrum lucidum Ait., Cornus officinalis, Dioscoreae Rhizoma, Rehmanniae Radix, Taxilli Herba, Achyranthes bidentata, Vaccariae Semen, Tetrapanax papyriferus, Glycyrrhiza | Diffuse liver qi to relieve depression and regulate blood to balance menstruation. | 30/30 | 96.7%/90.0% | 3 months | Estradiol tablets/didrogesterone tablets | FSH, E2↓, AMH↑ | [29] |
Liver and Kidney Yin deficiency syndrome | Bushen Tianjing Formula | Testudinis Carapax et Plastrum, Rehmanniae Radix, Cuscuta chinensis, Fructus Ligustri Lucidi | Tonify the kidneys and replenish essence. | 20/10 | 87.5%/55.0% | 3 months | Estradiol valerate tablets/estradiol cyproterone tablets | FSH, LH↓ | [23] |
Kidney deficiency with Blood stasis syndrome | Bushen Huoxue Decoction | Rehmanniae Radix, Angelicae Sinensis Radix, Cynanchum otophyllum Schneid, Dioscoreae Rhizoma, Corni Fructus, Lycii Fructus, Eucommia ulmoides, Cuscuta chinensis, Polygoni Multiflori Radix, Cistanches Herba, Astragali Radix | Tonify the kidneys, replenish essence, invigorate blood | 39/34 | NA | 3 months | Ubidecarenone Soft Capsules | FSH, E2, LH↓, AMH↑ | [33] |
Spleen and Kidney deficiency syndrome | Bushen Jianpi Formula | Astragali Radix, Cuscuta chinensis, Dioscoreae Rhizoma, Atractylodis Macrocephalae Rhizoma, Achyranthes bidentata, Codonopsis Radix, Rehmanniae Radix, Eucommia ulmoides, Angelicae Sinensis Radix, Ligusticum chuanxiong hort., Poria, Taxilli Herba, Dipsaci Radix, Cornus officinalis, Glycyrrhizae Radix et Rhizoma | Tonify the kidneys and strengthen the spleen. | 50/50 | NA | 3 months | Vitamin E softgel | FSH, AFC, AMH↑ | [34] |
Liver and Kidney Yin deficiency syndrome | Zi Gui Nv Zhen capsules | Fructus ligustri Lucidi, Cordyceps, Radix rehmanniae preparata, Radix panacis quinquefolii, Radix angelicae sinensis, Radix astragali, Fructus corni | Tonify the liver and benefit the kidneys, nourish yin and replenish blood. | 75/34 | NA | 3 months | NA | FSH, LH↓, AFC, E2, AMH↑ | [27] |
Kidney Deficiency with Blood Stasis syndrome | Tiaojing Kangshuai Decoction | Rehmanniae Radix, Dioscoreae Rhizoma, Multiflori Radix, Eclipta Prostrata, Cornus officinalis, Fructus Ligustri Lucidi, Paeoniae Radix Rubra, Placenta Hominis, Persicae Semen, Carthami Flos, Glycyrrhizae Radix et Rhizoma | Invigorate the blood and resolve blood stasis, tonify the kidneys and replenish essence. | 40/40/40 | 92.50%/70.00%/75.00% | 3 months | Estradiol valerate tablets + progesterone capsules | FSH, LH↓, E2↑ | [25]. |
Kidney Deficiency with Blood Stasis syndrome | Bushen Huoxue formula | Cuscuta chinensis, Dipsaci Radix, Taxilli Herba, Rehmanniae Radix, Pseudostellariae Radix, Poria, Cinnamomi Ramulus, Radix Rubra, Persicae Semen, Moutan Cortex, Cornus officinalis, Uncaria rhynchophylla, Asini Corii Colla | Benefit Qi and nourish the blood, nourish Yin and tonify the kidneys. | 64/64 | 96.88%/85.94% | 8 weeks | Dehydroepiandrosterone | FSH, LH, E2↓, PSV, VFI, FI↑ | [28] |