Table 3 The regulatory effects of active compounds in CHMs on DOR
From: The role of Chinese herbal medicine in diminished ovarian reserve management
Components | Classification | Model | Dose | Treatment period | Target | Plants source | Mechanisms | Ref |
|---|---|---|---|---|---|---|---|---|
Curcumin | Polyphenols | 21-day-old female NMRI mice | 100 mg/Kg | Daily, 12 Weeks/ 33 Weeks | GDF-9, BMP-15, SIRT-1, SIRT-3 | Curcuma longa L. | Oxidative stress | [86] |
Hyperoside | Flavonoid | 6-week-old C57BL/6 female mice, KGN cells | 40 mg/Kg, 10 μM/L | Daily, 5 weeks | HIF-1α, bnip3,LC3B-II, Beclin1, P62 | Hypericum perforatum L. | Autophagy | [108] |
Kaempferol | Flavonoid | 27-week-old C57BL/6 female mice | 100 mg/kg | Daily, 4 weeks | HSP90, NRF2, HSF1, p-HSF1, Src, p-SRC | Forsythia suspensa | Oxidative stress | [85] |
Paeoniflorin | Diterpenoid glycosides | 6-week-old female Kunming mice, KGN cells | 150 mg/kg, 10 μM/L | Daily, 4 weeks | FSHR, cAMP, PKA, CREB | Paeonia lactiflora Pall. | Restore ovarian granulosa cell function | [116] |
Pueratin | Saponins | 4-week-old Female SD rats | 300 mg/kg | Daily, 45 days | Caspase-3, Bcl-2, Bax | Puerariae Lobatae Radix | Inhibit apoptosis | [87] |
Rehmannioside D | Iridoid | 8-week-old Female SD rats | 76 mg/kg | Daily, 2 weeks | FOXO1, KLOTHO, Bax, Bcl-2 | Rehmannia glutinosa | Inhibit apoptosis | [99] |
Resveratrol | Polyphenol | 70-day-old female Wistar Albino rats | 20 mg/kg | Daily, 45 days | NA | Veratrum album | Inhibit apoptosis | [103] |
Isoquercitrin | Flavonols | KGN cells | 10 μM/L | 24 h | HO-1, Nrf2, p-eIF2α, eIF2α, P-ERK, Gclc, Gclm, Gsr, Keap1, Fxol1, Srxn1, Txnrd1, Rhob, Pon2, Hepud1, Selenok, Dnajb1,Ddit3, Sesn2, Dhcr24 | Cercis canadensis | Oxidative stress | [90] |
Soy isoflavones | Flavonoid | 12-month-old female Wistar albino rats | 150 mg/kg | Daily, 8 days | cleaved-caspase-3, bcl2 | Glycine max | Inhibit apoptosis and oxidative stress | [91] |
Urtica pilulifera L. seed extract | NA | 6-8-week-old female Balb/c mice | 200 mg/kg | Daily, 14 days | NA | Urtica fissa | Inhibit apoptosis and oxidative stress | [105]. |
Osthole | Coumarins | 10-week-old Female SD rats | 80 μg·mL | Daily, 21 days | AMH, E2、IL-4, IL-10, TNF-α, Nrf2, HO-1, NLRP3 | Cnidium monnieri | Inflammatory response and oxidative stress | [92] |
Total Flavones from Semen Cuscutae | Flavonoid | 21-day-old Female SD rats | 530.1 mg/kg | Daily, 4 weeks | FSHR, PKA, p-PKA | Cuscuta chinensis | Restore ovarian granulosa cell function | [114] |