Fig. 2

Tanshinone IIA can mitigate the impact of TOCP on the development of the ovaries. Morphological changes of ovaries treated with a vehicle control (A), 200 mg/kg/d TOCP (B), 200 mg/kg/d TOCP + 25 mg/kg/d tanshinone IIA (C) or 200 mg/kg/d TOCP + 50 mg/kg/d tanshinone IIA (D) (n = 3). Scale bars represent 100 μm. (E) Quantification of ovarian follicle types in mice ovaries after treatment with a vehicle control, 200 mg/kg/d TOCP, 200 mg/kg/d TOCP + 25 mg/kg/d tanshinone IIA or 200 mg/kg/d TOCP + 50 mg/kg/d tanshinone IIA (n = 3). The data are presented as mean ± SEM from at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001