Fig. 9

Molecular mechanism schematic diagram illustrating the recovery effect of tanshinone IIA on TOCPinduced ovarian dysfunction. TOCP induces ovarian apoptosis mediated by inhibiting the YAP phosphorylation, ultimately leading to ovarian dysfunction. Tanshinone IIA stimulates the YAP phosphorylation, causing its retention in the cytoplasm. Unphosphorylated YAP translocates to the nucleus and enhances the expression of downstream target genes CCN1 and CCN2. Upregulation of CCN2 promotes the phosphorylation of AKT, ERK1/2, and P38 signaling pathways, ultimately inhibiting ovarian apoptosis and reversing TOCP-induced ovarian dysfunction