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Table 3 IVF cycle protocols and clinical characteristics of probands from two families treated at our hospital

From: A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome

Proband

Age (years)

Duration of infertility (years)

Treatment

Ovulation induction regimen

Gn initial dose

Trigger dose

Retrieved oocytes

MII oocytes

Oocytes with abnormal morphology (n)

Fertilized outcomes

Clinical outcomes

Family 1 II-3

42

17

IVF

Luteal-phase long protocol

NA

hCG 8000 IU intramuscular

0

0

All empty follicle (n = 10)

0

Not pregnant

   

IVF

Antagonist dual trigger protocol

2550 IU

hCG 10,000 IU intramuscular Decapeptyl 0.1 mg subcutaneous

0

0

All empty follicle (n = 3)

0

Not pregnant

Family 2 II-1

32

4

IVF

Antagonist single trigger protocol

2025 IU

hCG 8000 IU intramuscular

0

0

All empty follicle (n = 8)

0

Not pregnant

   

IVF

Natural cycle protocol

NA

hCG 8000 IU intramuscular

0

0

All empty follicle (n = 1)

0

Not pregnant

  1. IVF: in vitro fertilization; Gn: gonadotropin; hCG: human chorionic gonadotropin; NA: not available