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Table 4 The probands from two families with gonadotropin stimulation and follicle response during IVF cycles

From: A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome

 

Family 1 II-3

Family2 II-1

IVF

IVF

IVF

IVF

Male age (years)

40

30

Female age (years)

42

32

Infertility(years)

17

4

Basal hormone concentrations

FSH (mIU/mL)

6.06

9.34

5.39

LH (mIU/mL)

3.27

5.77

2.87

E2 (pmol/L)

100.08

184.8

128.1

P (nmol/L)

0.42

1.19

1.85

PRL (ng/mL)

15.56

17.7

10.86

Hormone concentrations on day of hCG administration

LH (IU/L)

2.8

1.55

3.4

15.73

E2 (pmol/L)

8506

6572

4401

549.9

P (nmol/L)

3.56

1.78

4.23

1.39

Period of Gn stimulation(days)

10

9

9

NA

No. of follicles (≥ 14 mm)

8

3

5

1

No. of total follicles

20

8

9

7

β-hCG level on the day of oocyte retrieval (IU/L)

NA

189.9

298

NA

No. of total oocytes obtained

0

0

0

0

  1. IVF: in vitro fertilization; FSH: follicle-stimulating hormone; LH: luteinizing hormone; E2: estradiol; P: progesterone; PRL: prolactin; Gn: gonadotropin; β-hCG: β-human chorionic gonadotrophin; NA: not available