Fig. 4
Correlation between DNA CpG site methylation and gene expression for validated HSGs. Dots represent the Pearson correlation coefficient between mean methylation (β) for CpG sites overlapping HSG coordinates and gene expression (log2 normalized counts). A negative correlation coefficient indicates a linear association between methylation and expression (hypermethylation-downregulation, hypomethylation-upregulation). HSGs for (A, B) CCC and (C, D) MC. Promoter: Promoter region (2000 bp upstream of the transcriptional start site (TSS), 200 bp downstream of TSS). CCC: Clear cell carcinoma, EC: Endometrioid carcinoma, HGSC: High-grade serous carcinoma, MC: Mucinous carcinoma